Moonlighting chaperone‐like activity of the universal regulatory 14‐3‐3 proteins
نویسندگان
چکیده
منابع مشابه
The Roles of Moonlighting Proteins in Bacteria 15 The Roles of Moonlighting Proteins in Bacteria
Moonlighting proteins, characterized by their multiple autonomous functions, have been detected in bacteria. Surprisingly, many of these proteins are conserved and involved in metabolic pathway or the cell stress response. They localise to the bacterial surface to take on additional activities, which have been hypothesised to contribute to bacterial virulence or bacterial benefit. In this revie...
متن کاملBioinformatics and Moonlighting Proteins
Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity. For this reason, it would be helpful that Bioinformatics could predict this multifunctionality, especially because of the large amounts of sequences from genome projects. In the present work, we analyze and descr...
متن کاملWhy study moonlighting proteins?
Moonlighting proteins comprise a class of multifunctional proteins in which a single protein performs multiple physiologically relevant biochemical or biophysical functions that are not due to gene fusions, multiple RNA splice variants, or pleiotropic effects (Jeffery, 1999). Classic examples include soluble enzymes that also bind to DNA or RNA to regulate translation or transcription (Figure 1...
متن کاملMoonlighting proteins in yeasts.
Proteins able to participate in unrelated biological processes have been grouped under the generic name of moonlighting proteins. Work with different yeast species has uncovered a great number of moonlighting proteins and shown their importance for adequate functioning of the yeast cell. Moonlighting activities in yeasts include such diverse functions as control of gene expression, organelle as...
متن کاملComputational characterization of moonlighting proteins.
Moonlighting proteins perform multiple independent cellular functions within one polypeptide chain. Moonlighting proteins switch functions depending on various factors including the cell-type in which they are expressed, cellular location, oligomerization status and the binding of different ligands at different sites. Although an increasing number of moonlighting proteins have been experimental...
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ژورنال
عنوان ژورنال: The FEBS Journal
سال: 2017
ISSN: 1742-464X,1742-4658
DOI: 10.1111/febs.13986